학력

• 2005.08.8 ~ 2006.07.20 시카고 Rosalind Franklin University
• 연세의대 졸업

경력

• 현재 건양대학교의료원 의생명연구원 명곡의과학연구소장
• 현재 건양대학교병원 산부인과 교수
• 2018.03 ~ 2021.12 건양대학교의료원 의생명연구원장
• 건양대학교병원 연구부장
• 건양대학교의과대학 산부인과학교실 주임교수
• 전 건국대학교 의과대학 교수
• 산부인과 전문의 취득 (세브란스병원 수련)

학회활동

연구업적

• 2023.02Genital tract infection and pelvic surgery contribute to the developmentof endometriosis [journal of reproductive immunology]
• 2022.11Cytotoxicity and cellular uptake of red-emitting organic-inorganic hybrid nanoparticles [COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPE]
• 2022.11Obesity enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on γδ T cells [Cell Reports]
• 2022.11Impairment of Decidualization of Endometrial Stromal Cells by hsa-miR-375 Through NOX4 Targeting [REPRODUCTIVE SCIENCES]
• 2022.10The miR-182-5p/NDRG1 Axis Controls Endometrial Receptivity through the NF-kappa B/ZEB1/E-Cadherin Pathway [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES]
• 2022.05Salicornia herbacea aqueous extracts regulate NLRP3 inflammasome activation in macrophages and trophoblasts [Journal of Medicinal Food]
• 2022.04Aconitate Decarboxylase 1 Deficiency Exacerbates Mouse Colitis Induced by Dextran Sodium Sulfate [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES]
• 2022.03Ceria-zirconia nanoparticles reduce intracellular globotriaosylceramide accumulation and attenuate kidney injury by enhancing the autophagy flux in cellular and animal models of Fabry disease. [Journal of Nanobiotechnology]
• 2022.02Comparison of Macrophage Immune Responses and Metabolic Reprogramming in Smooth and Rough Variant Infections of Mycobacterium mucogenicum. [International Journal of Molecular Sciences]
• 2021.12Maternal and fetal safety of intravenous immunoglobulin in women with reproductive failure [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2021.11Targeting TBK1 Attenuates LPS-Induced NLRP3 Inflammasome Activation by Regulating of mTORC1 Pathways in Trophoblasts [frontiers in immunology]
• 2021.11임신 관련 3종 한약 처방 물 추출물과 목단피 에탄올 추출물이 자궁내막과 태반세포에 미치는 영향 [대한한방부인과학회지]
• 2021.083종 한약 처방과 황금에 의한 자궁내막과 태반세포 기능조절 연구 [대한한방부인과학회지]
• 2021.06Menopause is an inflection point of age-related immune changes in women [JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2021.04Inherited thrombophilia and anticoagulant therapy for women with reproductive failure [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2021.02Quantitative proteomic profiling of Cervicovaginal fluid from pregnant women with term and preterm birth [PROTEOME SCIENCE]
• 2021.02Tumor hypoxia represses gamma delta T cell-mediated antitumor immunity against brain tumors [NATURE IMMUNOLOGY]
• 2021.02Receptor-interacting protein kinase 2 contributes to host innate immune responses against Fusobacterium nucleatum in macrophages and decidual stromal cells [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2021.01Real-Time Tracking of Highly Luminescent Mesoporous Silica Particles Modified with Europium beta-Diketone Chelates in Living Cells [NANOMATERIALS]
• 2020.10Verbascoside-Rich Abeliophyllum distichum Nakai Leaf Extracts Prevent LPS-Induced Preterm Birth Through Inhibiting the Expression of Proinflammatory Cytokines from Macrophages and the Cell Death of Trophoblasts Induced by TNF-alpha [MOLECULES]
• 2020.09COVID-19 and immunomodulation treatment for women with reproductive failures [JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2020.05Multivalent DNA vaccine protects against genital herpes by T-cell immune induction in vaginal mucosa [Antiviral Research]
• 2020.04Sestrin2 alleviates palmitate-induced endoplasmic reticulum stress, apoptosis, and defective invasion of human trophoblast cells [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2020.04Tendril extract of Cucurbita moschata suppresses NLRP3inflammasome activation in murine macrophages and human trophoblast cells [International Journal of Medical Sciences]
• 2020.03SIRT1 Alleviates LPS-Induced IL-1 beta Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts [CELLS]
• 2020.02Vaginal Microbiota Profiles of Native Korean Women and Associations with High-Risk Pregnancy [JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY]
• 2019.10SIRT1 negatively regulates invasive and angiogenic activities of the extravillous trophoblast [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2019.10Ureaplasma Urealyticum Infection Contributes to the Development of Pelvic Endometriosis Through Toll-Like Receptor 2 [FRONTIERS IN IMMUNOLOGY]
• 2018.05Fas and FasL genetic polymorphisms in women with recurrent pregnancy loss: a case-control study [Human Fertility]
• 2018.02Vitamin D facilitates trophoblast invasion through induction of epithelial-mesenchymal transition [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2018.02Nematicidal activity of grammicin produced by Xylaria grammica KCTC 13121BP against Meloidogyne incognita [Pest Management Science]
• 2018.02Prolactin receptor gene polymorphism and the risk of recurrent pregnancy loss: a case-control study [Journal of Obstetrics and Gynaecology]
• 2018.02Unsaturated fatty acids protect trophoblast cells from saturated fatty acid-induced autophagy defects [JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2018.01Immune modulation of i.v. immunoglobulin in women with reproductive failure [Reproductive Medicine and Biology]
• 2017.12Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Recurrent Pregnancy Loss: a Case-Control Study [JOURNAL OF KOREAN MEDICAL SCIENCE]
• 2017.08Trophoblasts regulate natural killer cells via control of interleukin-15 receptor signaling [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2017.08Trends in Fetal and Perinatal Mortality in Korea (2009-2014): Comparison with Japan and the United States [JOURNAL OF KOREAN MEDICAL SCIENCE]
• 2017.08Activation of NOD-1/JNK/IL-8 signal axis in decidual stromal cells facilitates trophoblast invasion [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2017.03Intravenous immunoglobulin G in women with reproductive failure: The Korean Society for Reproductive Immunology practice guidelines [Clinical and Experimental Reproductive Medicine]
• 2017.01Single port access laparoscopic surgery for large adnexal tumors: Initial 51 cases of a single institute [Obstetrics & Gynecology Science]
• 2016.01Intravenous Immunoglobulin G Improves Pregnancy Outcome in Women with Recurrent Pregnancy Losses with Cellular Immune Abnormalities [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2015.09No association of p53 codon 72 polymorphism with idiopathic recurrent pregnancy loss in Korean population [EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE]
• 2015.08Estrogen receptor beta gene polymorphisms and risk of recurrentpregnancy loss: a case?control study [GYNECOLOGICAL ENDOCRINOLOGY]
• 2015.02.01Immune Cells in the Female Reproductive Tract [대한면역학회]
• 2015.02Immune Cells in the Female Reproductive Tract [Immune Network]
• 2014.12.01폐경 여성에서 비타민 D 농도에 따른 말초혈액의 림프구 아형의 변화 [대한골다공증학회]
• 2014.12.01The PAI-1 4G/5G and ACE I/D Polymorphisms and Risk of Recurrent Pregnancy Loss: A Case-Control Study [WILEY-BLACKWELL]
• 2014.12The PAI-1 4G/5G and ACE I/D Polymorphisms and Risk of Recurrent Pregnancy Loss: A Case-Control Study [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2014.12폐경 여성에서 비타민 D 농도에 따른 말초혈액의 림프구 아형의 변화 [OSTEOPOROSIS]
• 2014.08.01Immunological Modes of Pregnancy Loss: Inflammation, Immune Effectors, and Stress [WILEY-BLACKWELL]
• 2014.08Immunological Modes of Pregnancy Loss: Inflammation, Immune Effectors, and Stress [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2014.05면역글로불린G는 반복유산 임신부의 말초혈액 Th17세포와 조절T세포를 조절하여 면역기능을 정상화한다(Intravenous Immunoglobulin G Modulates Peripheral BloodTh17 and Foxp+ regulatory T cells in pregnant women with recurrent pregnancy loss) [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2013.09반복유산의 진단에 유용한 세포면역마커 발굴과 기준치 결정(Determination of clinical cellular immune markers in women with recurrent pregnancy loss) [AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY]
• 2013.03지역별 분만서비스 접근도에 따른 산과적 합병증 비교 [농촌의학.지역보건]
• 2012.07항SSA/Ro항체와 항-SSB/La 항체 양성으로 인한 태아의 선천성 심장부정맥이 발생한 전신홍반성낭창(SLE, 루프스) 임신부에게 임신 중 스테로이드 약물투여로 심장부정맥 치료 증례(Prevention of anti-SSA/Ro and anti-SSB/La antibodies-mediated congenital heart block in pregnant woman with systemic lupus erythematosus: A case report) [Obstetrics & Gynecology Science]
• 2012.04반복유산 환자에게 Th17세포와 조절T세포의 중요성(Th17 and Regulatory T cells in Women with Recurrent Pregnancy Loss.) [Am J Reprod Immunol]
• 2012.02반복유산 환자의 임신제1삼분기 융모세포(태반세포)에서 Kisspeptin과 수용체 GPR54의 발현 연구(Expression of Kisspeptin and its Receptor GPR54 in the First Trimester Trophoblast of Women with Recurrent Pregnancy Loss) [Am J Reprod Immunol]
• 2012.01자궁내막에서 p57kip2 단백의 표현과 호르몬에 의한 조절 연구(Cyclic Changes in the Expression of p57kip2 in Human Endometrium and its Regulation by Steroid Hormones in Endometrial Stromal Cells In Vitro) [Reproductive Sciences]
• 2011원인불명 반복유산 환자는 면역활성세포인 인터루킨17 생산 T세포와 면역조절세포인 조절T세포간에 불균형이 있다.(An imbalance in interleukin-17-producing T and Foxp3 regulatory T cells in women with idiopathic rec) []
• 2011Foxp3단백의 발현이 높은 T세포와 낮은 T 세포는 Th1세포와 자연살해세포와 각기 다르게 상관성을 보인다(Foxp3(high) and Foxp3(low) Treg cells differentially correlate with T helper 1 and natural killer c) []
• 2010건강한여성의 월경주기 동안 말초혈액 T, B, 자연살해세포의 변화 연구(Fluctuation of Peripheral Blood T, B, and NK Cells during a Menstrual Cycle of Normal Healthy Women) []
• 2009면역글로부린에 의한 임프구의 분포와 활성에 미치는 영향 []
• 2009골다공증이 있는 한국 폐경여성에서 골다공증 치료제로서 비스포스포네이트 제제들의 효과에 대한 비교연구 []
• 2009여성불임과 자가면역질환 []
• 2009배아 착상에 자궁내막 면역세포의 역할(The role of immunoglobulin i recurrent abortion) []
• 2009습관성유산 치료의 최신동향 []
• 2009한국인 반복유산 환자의 혈전성향증 빈도 []
• 2008황체파열을 동반한 전신성홍반성 루프스 1예 []
• 2008정상 난소와 난소종양에서 p57kip2의 발현에 관한 연구 []
• 2004자궁외임신에서 치료적 방법에 따른 평균 재원일수와 입원비용에 관한 연구 []
• 20042004.3 생쥐의 자궁내막에서 p27kip과 p57kip2의 발현 []
• 2004생쥐고환의 출생후 발생에 따른 p57kip2담백질의 발현 []
• 2004자궁외임신의 임상적특성과 치료선택에 관한 연구 []
• 2004생쥐의 발정주기와 착상전, 후기 자궁내막에서 p57kip2단백질의 발현 []
• 2003사람의 융모막암 JEG-3세포에서 CDK Inhibitor인 p27kip1 과 p57kip2의 발현 []
• 2003생쥐의 생후 정소발생동안 CDK inhibitor인 p27kip1 과 p57kip2의 발현 []
• 2003"생쥐의 생후발생동안 CDK inhibitor인 p27kip1과 p57ip2의 발현 []
• 2003사람의 자궁내막세포에서 생리주기별 c-Src 와 Csk의 발현 []
• 2003생쥐의 태반에서 p27kip1과 p57kip2의 발현 []
• 2003사람의 생리기간동안 자궁내막에서 CDK Inhibitor인 p27kip1 과 p57kip2의 발현 []
• 2003임신중기 양수천자 전후의 제대동맥에서 도플러 변화 양상 []
• 2002자궁경부암 진단시 자궁경부확대촬영술의 유용성 []
• 2002산전초음파로 진단된 다낭성 이형성신 1예 []
• 2001태아 염색체 이상 진단을 위한 Dual market검진의 유용성 [건양의대학술지 1권 1호]
• 2001침윤성 외음부 혈관점액종 1부 [건양의대학술지 1권 1호]
• 2000조혈모세포로부터 분화유도된 수상돌기세포에서 항원유입능력 및 MHC분자표현의 변화 [대한면혁학회지 22권 2호]
• 2000전국의대에서 경험한 세가지 문제 중심 학습 유형 [한국의학교육 12권 2호]
• 1999조기 양막파수의 진단방법으로 질세적액 내 Human Chorionic Gonadotropin 검사의 유용성 [건대의과학학술지 8권 2호]
• 1999침윤성 자궁경부암에서 맥관형성에 관한 연구 [대한산부인과학회지 42권 3호]
• 1999임신중 항간질약을 사용한 간질산모의 불량한 임신예후 [대한산부인과학회지 42권 1호]
• 1998폐경 환자에게 호르몬치료시 뇨증 N-Telopeptide의 유용성 [건대의과학학술지]
• 1998거대 난소부종 1예 [대한산부인과학회지 41권 6호]
• 1997침윤성 자궁경부암에서 p53과발현에 관한 연구 [대한산부인과학회지 40권 8호]
• 1997간의 우엽에서 발견된 복강임신 [대한산부인과학회지 40권 5호]
• 1996임신시 동반된 급성지방간 1례 []
• 1995이신말기에 발견된 포상기태와 정상태아 [건대의과학학술지 5권]
• 1992자궁내막 낭종과 동반된 무증상의 직장내의 자궁내의 자궁내막중 1예 [대한산부인과학회지 35권]
• 1992난소의 악성 배세포종양 [대한산부인과학회지]
• 1990난소종양에 관한 병리 조직학 및 세포 유전학적 비교연구 [대한산부인과학회지 33]
• 1990도프러제대동맥 혈류속도 파형치의 측정부위에 따른 비획일성 [대한주산기의학회지]
• 1990난소의 악성배세포종양 []