학력

• 가톨릭대학교대학원 의학과 신경과학 석사, 박사
• 이화여자대학교 의학과 졸업

경력

• 현) 건양대학교병원 신경과 교수
• 2021 치매극복의날 기념 복지부장관 표창 수상
• 2016 치매극복의날 대전시장 표창 수상
• Helen Wills Neuroscience Institute, UC Berkeley 연수
• 2017년 세계 3대 인명사전중 하나인 마르퀴즈 후즈 후 등재
• 건양대학교병원 신경과 조교수, 부교수
• 가톨릭대학교 인천성모병원 임상강사
• 가톨릭대학교 성모병원 인턴, 레지던트

학회활동

• 2021 대한신경과학회 추계학술대회 우수발표상
• 대전시 서구지역사회치매협의체 자문위원
• 대한치매학회 연구이사
• 대한 파킨슨병 및 이상운동질환 학회 정회원
• 대한 신경과 학회 정회원, 학술위원

연구업적

• 2022.12Transferability of Alzheimer disease polygenic risk score across populations and its assocation with Alzheimer disease-related phenotypes [JAMA network open]
• 2022.04Association between sleep parameters and longitudinal shortening of telomere length [Aging-US]
• 2022.03Cilostazol versus aspirin on white matter changes in cerebral small vessel disease: a randomized controlled trial [Stroke]
• 2022.01Serum neurofilament light chain level as a predictor of cognitive stage transition [ALZHEIMERS RESEARCH & THERAPY]
• 2022.01Association Between Body Mass Index and Cognitive Function in Mild Cognitive Impairment Regardless of APOE ε4 Status [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2022.01Clinical Practice Guideline for Dementia (Diagnosis and Evaluation): 2021 Revised Edition [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2022Abnormal tau in amyloid PET negative individuals [Neurobiology of Aging]
• 2022Transferability of Alzheimer disease polygenic risk score across populations and its assocation with Alzheimer disease-related phenotypes [JAMA network open]
• 2022Pattern of dementia treatment in older adults with Parkinson's disease using nationwide medical claims data [BMC geriatrics]
• 2022Association between sleep parameters and longitudinal shortening of telomere length [Aging]
• 2022Cilostazol versus aspirin on white matter changes in cerebral small vessel disease: a randomized controlled trial [Stroke]
• 2022Association between body mass index and cognitive function in mild cognitive impairment regardless of APOE e4 status [Dementia and Neurocognitive Disorders]
• 2022Clinical practice guideline for dementia (Diagnosis and evaluation): 2021 revised edition [Dementia and Neurocognitive Disorders]
• 2022Serum neurofilament light chain level as a predictor of cognitive state transition [Alzheimer's Research & Therapy]
• 2021.06Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population [ALZHEIMERS RESEARCH & THERAPY]
• 2021.03A systematic review and meta-analysis of the clinical effects of Souvenaid in patients with Alzheimer's disease [ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION]
• 2021.02Cognitive trajectories of patients with focal ss-amyloid deposition [ALZHEIMERS RESEARCH & THERAPY]
• 2021.01Alzheimer's cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans CSF AD biomarkers measured by Lumipulse in Koreans [ALZHEIMERS RESEARCH & THERAPY]
• 2021.01Tarsal tunnel syndrome in patients with fibromyalgia [ARCHIVES OF RHEUMATOLOGY]
• 2021Alzheimer's cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans [Alzheimer's Research & Therapy]
• 2021Cognitive decline according to amyloid uptake in patients with poststroke cognitive impairment [Medicine]
• 2021Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population [Alzheimer's Research & Therapy]
• 2021A systematic review and meta-analysis of the clinical effects of Souvenaid in patients with Alzheimer's disease [Asia Pacific Journal of Clinical Nutrition]
• 2021Cognitive trajectories of patients with focal ss-amyloid deposition [Alzheimer's Research & Therapy]
• 2020.11Diagnostic and therapeutic biomarkers for Alzheimer's disease in human-derived platelets [Genes & Genomics]
• 2020.03Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer's disease [Aging US]
• 2020.01Clinical significance of focal ß-amyloid deposition measured by 18 F-flutemetamol PET [ALZHEIMERS RESEARCH & THERAPY]
• 2020Conscientiousness is associated with less amyloid deposition in cognitively normal aging [Psychology and Aging]
• 2020Clinical significance of focal ß-amyloid deposition measured by 18F-flutemetamol PET [Alzheimer's Research & Therapy]
• 2020Balance and Mobility Performance Along the Alzheimer’s Disease Spectrum [Journal of Alzheimer's Disease]
• 2020Balance and Mobility Performance Along the Alzheimer's Disease Spectrum [Journal of Alzhiemers Disease]
• 2020Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer's disease [Aging US]
• 2020Clinical significance of focal b-amyloid deposition measured by 18F-flutemetamol PET [Alzheimers Research & Therapy]
• 2020Diagnostic and therapeutic biomarkers for Alzheimer's disease in human-derived platelets [Genes & Genomics]
• 2019.12A Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes: Protocol of a Multicenter, Randomized Controlled Trial [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2019.11Prediction of cognitive impairment viadeep learning trained with multi-centerneuropsychological test data [BMC MEDICAL INFORMATICS AND DECISION MAKING]
• 2019.08서울신경심리검사-단축형의 지역사회 치매 관리 사업 인지평가도구로써 효용성 [대한신경과학회지]
• 2019.04Association of Nutritional Status with Cognitive Stagein the Elderly Korean Population:The Korean Brain Aging Study for the Early Diagnosis andPrediction of Alzheimer’s Disease [JOURNAL OF CLINICAL NEUROLOGY]
• 2019.03Clinical and Biomarker Characteristics According toClinical Spectrum of Alzheimer’s Disease (AD) in theValidation Cohort of Korean Brain Aging Study forthe Early Diagnosis and Prediction of AD [JOURNAL OF CLINICAL MEDICINE]
• 2019Prediction of cognitive impairment via deep learning trained with multi-center neuropsychological test data [BMC Medical Informatics and Decision Making]
• 2019Clinical and Biomarker Characteristics According to Clinical Spectrum of Alzheimer's Disease (AD) in the Validation Cohort of Korean Brain Aging Study for the Early Diagnosis and Prediction [Journal of Clinical Medicine]
• 2019A Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes: Protocol of a Multicenter, Randomized Controlled Trial [Dementia and Neurocognitive Disorder]
• 2019Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease [Journal of clinical Neurology]
• 2019서울신경심리검사-단축형의 지역사회 치매 관리 사업 인지평가도구로써 효용성 [대한신경과학회지]
• 2018.10Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study [JOURNAL OF ALZHEIMERS DISEASE]
• 2018.07Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer’s Disease Using Clinical Research Center for Dementia of South Korea Data [JOURNAL OF CLINICAL NEUROLOGY]
• 2018Age-specific Cutoff Scores on a T1-Weighted Axial Medial Temporal Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data [Journal of Clinical Neurology]
• 2018Prospective Memory Loss and Related White Matter Changes in Patients wit hAmnestic Mild Cognitive Impairment [Dementia and Neurocognitive Disorders]
• 2018Effect of Physical Activity on the Progression of Alzheimer's Disease: The clinical Research Center for Dementia of South Krea Study [Journal of alzheimer's Disease]
• 2017.11Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study [JOURNAL OF ALZHEIMERS DISEASE]
• 2017.08Efficacy and tolerability of rivastigmine patch therapy in patients with mild-to-moderate Alzheimer's dementia associated with minimal and moderate ischemic white matter hyperintensities: A multicenter prospective open-label clinical trial [PLOS ONE]
• 2017.06고립성 폐결절 절제술 중 페닐에프린 투약에 의해 발생한 가역적 후백질 뇌병증 증후군 [대한신경집중치료학회지]
• 2017.05Hippocampal and entorhinal structures in subjective memory impairment: a combined MRI volumetric and DTI study [INTERNATIONAL PSYCHOGERIATRICS]
• 2017.01Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes [JOURNAL OF THE NEUROLOGICAL SCIENCES]
• 2017.01Flail arm syndrome with several issues related to the diagnostic process [Annals of Clinical Neurophysiology]
• 2017Efficacy and tolerability of rivastigmine patch therapy in patients with mild-to-moderate Alzheimer's dementia associated with minimal and moderate ischemic white matter hyperintensities: A multicenter prospective open-label clinical trial [PLOS one]
• 2017Hippocampal and entorhinal structures in subjective memory impairment: a combined MRI volumetric and DTI study [INTERNATIONAL PSYCHOGERIATRICS]
• 2017Anosognosia and Its Relation to Psychiatric Symptoms in Early-Onset Alzheimer Disease [JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY]
• 2017Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes [JOURNAL OF THE NEUROLOGICAL SCIENCES]
• 2017Prediction model of conversion to dementia risk in subjects with amnestic mild cognitive impairment: A longitudinal, multi-center clinic-based study [Journal of Alzheimers Disease]
• 2016.09Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2016Differences in depressive patterns according to disease severity in early-onset Alzheimer's disease [Journal of Alzheimers Disease]
• 2016Clinical predictors for mild cognitive impairment progression in Korean cohort [Dementia and Neurocognitive Disorders]
• 2016Default mode network functional connectivity in early and late mild cognitive impairment [Alzheimer Disease & Associated Disorders]
• 2015.11Gray and white matter degeneration in subjective memory impairment: comparisons with normal controls and mild cognitive impairment. [JOURNAL OF KOREAN MEDICAL SCIENCE]
• 2015.11거미막낭종에 의한 편측 단독설하신경마비 [대한신경과학회지]
• 2015.11재발 시신경염 기왕력이 있는 Balo동심경화증 [대한신경과학회지]
• 2015.10Unstable body mass index and progression to probable Alzheimer's disease dementia in patients with amnestic mildcognitive impairment [JOURNAL OF ALZHEIMERS DISEASE]
• 2015.09Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS) [DEMENTIA AND GERIATRIC COGNITIVE DISORDERS]
• 2015.06Cognitive Correlates of Cerebral Vasoreactivity on Transcranial Doppler in Older Adults [JOURNAL OF STROKE & CEREBROVASCULAR DISEASES]
• 2015.06경도인지장애 환자의 집단 작업치료 및 음악치료의 효과 [노인병]
• 2015.03Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer’s Disease [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2015.03Anatomical Correlates of the “Closing-In” Phenomenon [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2015.01Cognitive Profiles and Neuropsychiatric Symptoms in Korean Early-Onset Alzheimer's Disease Patients: A CREDOS Study [JOURNAL OF ALZHEIMERS DISEASE]
• 2014.12.31치매환자들의 운전실태: 노인성치매임상연구센터 연구 [대한치매학회]
• 2014.12.01후대뇌동맥 신연증에 의한 압박성 동안신경 마비 [대한안신경의학회]
• 2014.12치매환자들의 운전실태: 노인성치매임상연구센터 연구 [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2014.05.01글루포시네이트암모늄(glufosinate ammonium, BASTA ? ) 중독 후 발생한 뇌병증 [대한신경과학회]
• 2014.05.01Do Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) progress differently? [ELSEVIER IRELAND LTD]
• 2014.05.01White Matter Hyperintensities in Mild Cognitive Impairment: Clinical Impact of Location and Interaction with Lacunes and Medial Temporal Atrophy [ELSEVIER SCIENCE BV]
• 2014.05.01Cognitive Profiles and Neuropsychiatric Symptoms in Korean Early-Onset Alzheimer's Disease Patients: A CREDOS Study [IOS PRESS]
• 2014.05글루포시네이트암모늄(glufosinate ammonium, BASTA ? ) 중독 후 발생한 뇌병증 [대한신경과학회지]
• 2014.05Do Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) progress differently? [ARCHIVES OF GERONTOLOGY AND GERIATRICS]
• 2014.03.01Korean-version of Mini-Mental State Examination 검사에서 기억회상 0점 노인을 대상으로 한 1년 뒤 치매 이행률에 대한 예비 연구 [대한노인병학회]
• 2014.03Korean-version of Mini-Mental State Examination 검사에서 기억회상 0점 노인을 대상으로 한 1년 뒤 치매 이행률에 대한 예비 연구 [Journal of The korean Geriatrics Society(노인병학회지)]
• 2013.11기억성 경도인지장애 환자에서 백질 고강도와 아포지질단백질 E 유전자형과의 상관관계 - Interaction of white matter hyperintensities (WMHs) and apolipoprotein E(APOE) genotypes on cognition in patients with amnestic mild cognitive impairment (aMCI) [ARCHIVES OF GERONTOLOGY AND GERIATRICS]
• 2013.09급성 뇌줄기경색증 이후의 배뇨장애 양상 - Pattern of voiding dysfunction after acute brainstem infarction [EUROPEAN NEUROLOGY]
• 2013.09Pattern of voiding dysfunction after acute brainstem infarction [EUROPEAN NEUROLOGY]
• 2013.08Dystrophinopathy 환자에서 임상적, 면역조직화학적, 웨스턴 블롯 및 유전자 분석 - Clinicical, immunohistochemical, Western blot, and genetic analysis in dystrophinopathy [JOURNAL OF CLINICAL NEUROSCIENCE]
• 2013.08Clinical, immunohistochemical, Western blot, and genetic analysis in dystrophinopathy [JOURNAL OF CLINICAL NEUROSCIENCE]
• 2013.07경도인지장애와 알츠하이머병 환자에서의 해마와 후대상회에서의 미세구조변화 : 확산텐서영상 연구 - Microstructural changes in the hippocampus and posterior cingulate in mild cognitive impairment and Alzheiemr`s disease: a diffusion tensor imaging study [NEUROLOGICAL SCIENCES]
• 2013.07Microstructural changes in the hippocampus and posterior cingulate in mild cognitive impairment and Alzheiemr`s disease: a diffusion tensor imaging study [NEUROLOGICAL SCIENCES]
• 2013.06수근관증후군에서 국소 스테로이드 주사 후 임상적, 전기생리학적 변화 [대한임상신경생리학회지]
• 2013.05기억성 경도인지장애 환자에서 도구적 일상생활수행능력과 백질 고강도의 상관관계: 단면연구 결과 - Correlation between instrumental activities of daily living and white matter hyperintensities in amnestic mild cognitive impairment: results of a cross-sectional study [NEUROLOGICAL SCIENCES]
• 2013.05Hemichorea caused by intracranial hemorrhage following contralateral herpes zoster ophthalmicus [JOURNAL OF CLINICAL NEUROSCIENCE]
• 2013.05반대측 눈대상포진 이후 발생한 뇌출혈로 인한 반쪽무도증 - Hemichorea caused by intracranial hemorrhage following contralateral herpes zoster ophthalmicus [JOURNAL OF CLINICAL NEUROSCIENCE]
• 2013.03백질 고강도 신호 측정을 위한 반자동화 방법 - A Semi-Automated Method for Measuring White Matter Hyperintensity Volume [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2013.03A Semi-Automated Method for Measuring White Matter Hyperintensity Volume [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2013.02경도인지장애 환자에서의 백질 고강도 연구 : 위치에 따른 임상적 영향과 열공경색, 내측 측두엽 위축 과의 상호작용 - White matter hyperintensities in mild cognitive impairment: clinical impact of location and interaction with lacunes and medial temporal atrophy []
• 2012.12오각형 그리기와 관련된 대뇌 회색질 영역 [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2012.05기억성 경도인지장애 환자에서 도구적 일상생활수행능력과 백질 고강도의 상관관계: 단면연구 결과 - Correlation between instrumental activities of daily living and white matter hyperintensities in amnestic mild cognitive impairment: results of a cross-sectional study [NEUROLOGICAL SCIENCES]
• 2012.03치매 환자는 누가 돌보는가:독거 치매 노인 현황과 주부양자 조사 연구 [Dementia and Neurocognitive Disorders(대한치매학회지)]
• 2011치매가 없는 노년층에서 시공간 능력에서의 문해와 교육의 영향 - Effect of literacy and education on the visuoconstructional ability of non-demented elderly individu [J Int Neuropsychol Soc]
• 2011일산화탄소 중독증 이후 단독 발생한 양측해마 병변 - Isolated bilateral hippocampal lesions following carbon monoxide poisoning. [Eur Neurol]
• 2011주관적인지장애와 경도인지장애를 어떤 증상으로 구분할 수 있는가 - Which symptoms can distinguish between subjective cognitive impairment (SCI) and mild cognitive impa [Arch Gerontol Geriatric]
• 2011하시모토갑상선염과 연관된 모야모야증후군 [대한신경과학회지]
• 2011심한 백질 고강도를 보이는 한국 치매 환자들의 APOE e4 대립유전자 상태 - APOE e4 allele status in Korean dementia patients with severe white matter hyperintensities. [J Alzheimers Dis]
• 2010알츠하이머병과 특발성 정상압 수두증에서 해마의 미세구조적 변성의 차이 : 확산 텐서 영상 - Differences in Microstructural Alterations of the Hippocampus in Alzheimer Disease and Idiopathic No []
• 2010알츠하이머병의 백질 손상 확인을 위한 확산텐서영상과 복셀 기반 형태측정법의 비교 - Comparison of diffusion tensor imaging and voxe-based morphometry to detect white matter damage in A []
• 2010알츠하이머병 및 혈관성치매 환자에서 렘난트양지질단백콜레스테롤의 증가:예비 연구 []
• 2010다발경화증의 초기증상으로 발현된 손의 발작성 국소성 근긴장이상증 - A Case of Paroxysmal Focal Hand Dystonia as the Initial Presentation of Multiple Sclerosis []
• 2009정상압 수두증 환자에서 Tc-99m ECD 뇌 확산 SPECT 의 복셀 기초 분석 - Voxel-based analysis of Tc-99m ECD brain perfusion SPECT in patients with normal pressure hydrocepha []
• 2009알츠하이머병에서 백질 변화 정도에 따른 혈중 요산수치 [대한치매학회지]
• 2008중추계 백질에 국한된 병변과 시신경염을 동반한 길랑-바레 증후군에서의 엡스타인-바 바이러스 감염 - Guillain-Barre syndrome with optic neuritis and a focal lesion in the central white matter fo []
• 2008금주 후 발생한 교뇌 중심부 및 교뇌외 수초용해증 - Central pontine and extrapontine myelinolysis after alcohol withdrawal []
• 2008정상 노화 과정에서 발생하는 대뇌 백질 변성의 영역 특이적 변화 : 확산 텐서 분석 - Region-specific changes of cerebral white matter during normal aging: A diffusion-tensor analysis []
• 2008경도인지장애 환자에서 뇌피질하 혈관 변화 정도에 따른 해마와 백질 변성의 차이 : 확산 텐서 영상의 신경심리학적 연관성 - Difference of the hippocampal and white matter microalterations in MCI patients according to the sev []
• 2008경도인지장애에서 보이는 피질-피질 경로의 비정상적 융합 : 확산 텐서 영상 연구 - Abnormal integrity of corticocortical tracts in mild cognitive impairment: A diffusion tensor imagin []
• 2008주관적기억장애 환자의 미래계획기억: 예비연구 [대한치매학회지]
• 2007원발성 정상압수두증 환자의 국소 뇌혈류 변화: statistical parametric mapping을 이용한 SPECT 분석 []
• 2006양안 완전 수직주시 마비를 보인 일측성 중뇌-간뇌 접합부 경색 1예 []
• 2006확산 텐서 영상을 통한 순수 소뇌 증후군 환자에서 보이는 조기 병리학적 변화 - Early pathological changes in the cerebellum of patients with pure cerebellar syndrome demonstrated [European Neurology]
• 2006대상회의 급성 두개 내 출혈과 관련된 일과성 완전 기억 상실증 - Transient global amnesia associated with acute intracerebral hemorrhage at the cingulate gyrus. [European Neurology]
• 2006급성 뇌경색 환자에서 확산텐서영상의 적용: 분할 비등방도의 유용성 [대한신경과학회지]
• 2006비전형적인 임상증상과 방사선 소견을 보인 뇌의 원발성 T-세포 림프종 1예 [대한치매학회지]
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